Same problem here. I tried to:
1. Uninstall OpenLDV
2. Delete USB device from Device Manager
3. Install FTDI driver 2.08.14
4. Install OpenLDV back (5.1)
When i roll it back to 2.12.28 FTDI driver - same result.
Some times when i plug U10 with opened LonWorks Interfaces window, i can see interface properties, so it communicate once, but after any click = "Device is Detached or In-Use"